Research

Local PI: Dr. Allan Skanes

A randomized controlled trial testing whether aggressive risk-factor modification combined with catheter ablation outperforms ablation alone for people with atrial fibrillationn

87 of 100 participants enrolled

Local PI: Dr. Allan Skanes

An alternative to AV node ablation following pacemaker insertion, this procedure involves isolating the atrial fibrillation to the left atrium through targeted ablation. This procedure, if successful, could result in less dependence on the pacemaker and lower risk of long-term issues with the heart.

1 of 20 participants enrolled

Local PI: Dr. Habib Khan

PULSED-AF is a study aimed at patients undergoing catheter ablation for atrial fibrillation using the pulse field technique. Research staff will follow patients following their ablation to review medications, assess quality of life, and monitor for recurrence of atrial fibrillation.

0 of 60 participants enrolled

Local PI: Dr. Habib Khan

The CABANA-RAFT HF pilot study is evaluating whether it is feasible to conduct a larger randomized clinical trial comparing catheter ablation-based rhythm control with rate-control therapy in patients who have atrial fibrillation (AF) and heart failure with mildly reduced or preserved ejection fraction.

0 of 16 participants enrolled

Local PI: Dr. Allan Skanes

An observational companion to RASTA-AF that follows patients who decline the randomized trial, comparing their characteristics, quality of life, and outcomes.

52 of 50 participants enrolled

Local PI: Dr. Allan Skanes

Evaluates whether closing the left atrial appendage with the WATCHMAN FLX device, in addition to oral anticoagulants, reduces strokes and blood clots more than anticoagulants alone.

16 of 20 participants enrolled

Local PI: Dr. Allan Skanes

Assesses whether a patient-tailored ablation strategy guided by atrial scar mapping, added to pulmonary vein isolation, improves outcomes over PVI alone in persistent AF.

Local PI: Dr. Habib Khan

Compares pharmacological rate control with a Pace-and-Ablate conduction system pacing strategy for patients with permanent AF and heart failure.

32 of 80 participants enrolled

Local PI: Dr. Habib Khan

Compares standard right ventricular pacing with left bundle branch pacing for patients who have heart block.

76 of 80 participants enrolled

Local PI: Dr. Allan Skanes

Catheter ablation is a treatment strategy for atrial fibrillation that aims to restore sinus rhythm. Following ablation, patients undergo monitoring to assess for recurrence of atrial fibrillation. This study is testing a new product designed by Myant Inc. It is a wearable smart textile garment that monitors heart rhythm via continuous ECG to assess for recurrence of atrial fibrillation following catheter ablation.

1 of 30 participants enrolled

Local PI: Dr. Jaimie Manlucu

Patients with aortic valvular disease may undergo transcatheter aortic valve implantation (TAVI) to treat their aortic valve pathology. Due to the anatomical proximity of the heart's electrical system, TAVI may cause conduction abnormalities and the treatment for these new conduction abnormalities remains debated.

4 of 20 participants enrolled

Local PI: Dr. Habib Khan

Tests whether physiological pacing reduces mortality and heart-failure care, improves activity and quality of life, and better preserves cardiac function than standard right-sided pacing.

47 of 100 participants enrolled

Local PI: Dr. Habib Khan

Evaluates ultrasound-guided delivery of pacing leads deep into the septum to reduce attempts, improve safety, and minimize procedure time and radiation.

15 of 152 participants enrolled

Local PI: Dr. Habib Khan

Tests a new diagnostic approach to distinguish Calcium Release Deficiency Syndrome (CRDS) from related conditions using the heart's response to pacing.

2 of 10 participants enrolled

Lead PI: Dr. Habib Khan

Builds a clinical registry to evaluate the risk factors and gene mutations associated with cardiovascular events in patients with left ventricular non-compaction.

68 of 2000 participants enrolled

Local PI: Dr. Habib Khan

A Canadian research database and biobank collecting healthcare information and samples from patients investigated and treated for inherited heart rhythm conditions.

1235 of 2500 participants enrolled

Local PI: Dr. Habib Khan

Gathers phenotypic, genotypic, treatment, and outcome data on a large cohort to better define the natural history of CRDS and identify prognostic and therapeutic tools.

0 of 100 participants enrolled

Local PI: Dr. Habib Khan

Establishes a registry, biobank, and imaging repository for patients with hypertrophic cardiomyopathy and carriers of related genetic variants to address knowledge gaps.

113 of 300 participants enrolled

Local PI: Dr. Habib Khan

This is a randomized drug trial that is double blinded and has a placebo. This drug is designed to reduce the burden of atrial fibrillation in adult participants.

5 of 10 participants enrolled

Local PI: Dr. Lorne Gula

Evaluates whether catheter ablation, compared with antiarrhythmic drug therapy, better controls death, ICD shocks, and ventricular tachycardia in patients with prior heart attack.

1 of 10 participants enrolled

Local PI: Dr. Habib Khan

Determines whether the drug tideglusib, compared with placebo, reduces the number of premature ventricular contractions in patients with arrhythmogenic cardiomyopathy.

3 of 10 participants enrolled